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Lab member

Nobuaki Ito MD, PhD

Division of Therapeutic Development for Intractable Bone Diseases,　　　　　　Graduate School of Medicine and Faculty of Medicine, The University of Tokyo　　Project Associate Professor

Osteoporosis Center, The University of Tokyo Hospital

Vice director

Hajime Kato MD, PhD

Associate Research Scientist in Pathology, Yale School of Medicine　　　　　　　Braddock Lab Members < Braddock Lab (yale.edu)

Naoko Hidaka MD

PhD student

Yoshitomo Hoshino MD

PhD student

Soichiro Kimura MD

PhD student

Takashi Sunouchi MD

PhD student

So Watanabe MD (from Department of Geriatric Medicine)

PhD student

Koki Irie MD

PhD student

Tomoko Ozaki

Technician

Achievements

  • Kato H, Kitamoto T, Kimura S, Sunouchi T, Hoshino Y, Hidaka N, Tsurutani Y, Ito N, Makita N, Nishikawa T, Nangaku M, Inoue K. Cardiovascular Outcomes of KCNJ5 mutated Aldosterone-Producing Adenoma: A Systematic Review. Endocr Pract. 2024 Apr 22:S1530-891X(24)00497-X. doi: 10.1016/j.eprac.2024.04.007. Epub ahead of print. PMID: 38657793.
  • Tanaka Y, Soen S, Hirata S, Okada Y, Fujiwara S, Tanaka I, Kitajima Y, Kubota T, Ebina K, Takashi Y, Inoue R, Yamauchi M, Okubo N, Ueno M, Ohata Y, Ito N, Ozono K, Nakayama H, Terauchi M, Tanaka S, Fukumoto S. The 2023 Guidelines for the management and treatment of glucocorticoid-induced osteoporosis. J Bone Miner Metab. 2024 Mar 28. doi: 10.1007/s00774-024-01502-w. Epub ahead of print. PMID: 38538869.
  • Tanaka H, Tamura M, Muto M, Kinoshita Y, Ito N, Oka A, Kitanaka S. A novel pathogenic variant in fibroblast growth factor 23 outside the furin-recognizing RXXR motif in an autosomal dominant hypophosphatemic rickets patient. Horm Res Paediatr. 2024 Mar 15. doi: 10.1159/000538388. Epub ahead of print. PMID: 38493780.
  • Ito N, Hidaka N, Kato H. Acquired Forms of Fibroblast Growth Factor 23-Related Hypophosphatemic Osteomalacia. Endocrinol Metab (Seoul). 2024 Mar 11. doi: 10.3803/EnM.2023.1908. Epub ahead of print. PMID: 38467164.
  • Hidaka N, Inoue K, Kato H, Hoshino Y, Koga M, Kinoshita Y, Takashi Y, Makita N, Fukumoto S, Nangaku M, Ito N. FGF-23, Left Ventricular Hypertrophy, and Mortality in Patients With CKD: A Revisit With Mediation Analysis. JACC Adv. 2024 Jan, 3 (1) .https://doi.org/10.1016/j.jacadv.2023.100747
  • Okajima K, Kobayashi H, Ito N, Kato H, Ishibashi Y, Zhang L, Tsuda Y, Tanaka S. Extended curettage for tumour-induced osteomalacia in the bone. Jpn J Clin Oncol. 2024 Jan 23:hyad180. doi: 10.1093/jjco/hyad180. Epub ahead of print. PMID: 38266040.
  • Tsuda Y, Yasunaga Y, Abe M, Hoshi K, Ito N, Kondo K, Okajima K, Zhang L, Kato H, Hidaka N, Tanaka S, Kobayashi H. Surgical and biochemical outcomes of phosphaturic mesenchymal tumors causing tumor-induced osteomalacia in the head and neck region. Oral and Maxillofacial Surgery Cases. 2023; 9 (4):100335. doi.org/10.1016/j.omsc.2023.100335.
  • Hidaka N, Murata H, Tachikawa K, Osaki K, Sekiyama T, Kinoshita Y, Kato H, Hoshino Y, Kimura S, Sunouchi T, Watanabe S, Nangaku M, Makita N, Michigami T, Ito N. The Effect of Asfotase Alfa on Plasma and Urine Pyrophosphate Levels and Pseudofractures in a Patient With Adult-Onset Hypophosphatasia. JBMR Plus. 2023 Nov 20;7(12):e10842. doi: 10.1002/jbm4.10842. PMID: 38130758; PMCID: PMC10731098.
  • Ito N, Hidaka N, Kato H. The pathophysiology of hypophosphatemia. Best Pract Res Clin Endocrinol Metab. 2023 Nov 30:101851. doi: 10.1016/j.beem.2023.101851. Epub ahead of print. PMID: 38087658.
  • Qian C, Ito N, Tsuji K, Sato S, Kikuchi K, Yoshii T, Miyata T, Asou Y. A PAI-1 antagonist ameliorates hypophosphatemia in the Hyp vitamin D-resistant rickets model mouse. FEBS Open Bio. 2023 Dec 5. doi: 10.1002/2211-5463.13745. Epub ahead of print. PMID: 38050660.
  • Arima T, Sugimoto K, Taniwaki T, Maeda K, Shibata Y, Tateyama M, Karasugi T, Tokunaga T, Sueyoshi T, Hisanaga S, Masuda T, Uehara Y, Yugami M, Matsushita K, Yonemitsu R, Kawakami J, Yoshimura N, Tanimura S, Kato H, Ito N, Inoue K, Bando K, Nakamura T, Miyamoto T. Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice. J Biol Chem. 2023 Nov 30:105512. doi: 10.1016/j.jbc.2023.105512. Epub ahead of print. PMID: 38042486.
  • Arai M, Ochi H, Sunamura S, Ito N, Nangaku M, Takeda S, Sato S. A Novel Long Noncoding RNA in Osteocytes Regulates Bone Formation through the Wnt/β-Catenin Signaling Pathway. Int J Mol Sci. 2023 Sep 4;24(17):13633. doi: 10.3390/ijms241713633. PMID: 37686441.
  • Kato H, Braddock DT, Ito N. Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments. Curr Osteoporos Rep. 2023 Aug 2. doi: 10.1007/s11914-023-00814-6. Epub ahead of print. PMID: 37530996.
  • Kato H, Kimura S, Taguchi M, Sunouchi T, Hoshino Y, Hidaka N, Edvige Foligno N, Koga M, Manaka K, Tamiya H, Kawakami M, Kage H, Yasunaga Y, Nangaku M, Makita N, Ito N. FGF23-related hypophosphatemia in a patient with small cell lung cancer: a case report and literature review. Endocr J. 2023 Jul 20. doi: 10.1507/endocrj.EJ23-0086. Epub ahead of print. PMID: 37468265.
  • Hoshino Y, Manaka K, Sato J, Asatsuma Y, Horikoshi H, Takeuchi M, Ito N, Fujita M, Yasunaga M, Matsuda K, Honda A, Maki H, Masamoto Y, Kurokawa M, Nangaku M, Makita N. Recurrent bilateral adrenal infarction with myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U): a case report. BMC Endocr Disord. 2023 Jun 5;23(1):128. doi: 10.1186/s12902-023-01384-5. PMID: 37277771.
  • Kobayashi H, Ito N, Nakai Y, Katoh H, Okajima K, Zhang L, Tsuda Y, Tanaka S. Patterns of symptoms and insufficiency fractures in patients with tumour-induced osteomalacia. Bone Joint J. 2023 May 1;105-B(5):568-574. doi: 10.1302/0301-620X.105B5.BJJ-2022-1206.R2. PMID: 37121579.
  • Kato H, Miyazaki H, Kimura T, Hoshino Y, Hidaka N, Koga M, Nangaku M, Makita N, Ito N. Clinical performance of a new intact FGF23 immunoassay in healthy individuals and patients with chronic hypophosphatemia. Bone Rep. 2023 Feb 2;18:101659. doi: 10.1016/j.bonr.2023.101659. PMID: 36817167; PMCID: PMC9932357.
  • Ramos P, Larson B, Ashrafzadeh-Kian S, Ito N, Kato H, Bornhorst JA, Algeciras-Schimnich A. Intact Fibroblast Growth Factor 23 (iFGF23) Concentrations in Hypophosphatemic Disorders. Endocr Pract. 2023 Jan 7:S1530-891X(23)00002-2. doi: 10.1016/j.eprac.2023.01.003. Epub ahead of print. PMID: 36627024.
  • Kato H, Koga M, Kinoshita Y, Hidaka N, Hoshino Y, Takashi Y, Arai M, Kobayashi H, Katsura M, Nakamoto Y, Makise N, Ushiku T, Hoshi K, Nangaku M, Makita N, Fukumoto S, Ito N. Utility of Multimodality Approach Including Systemic FGF23 Venous Sampling in Localizing Phosphaturic Mesenchymal Tumors. J Endocr Soc. 2022 Nov 24;7(2):bvac181. doi: 10.1210/jendso/bvac181. PMID: 36540156; PMCID: PMC9757682.
  • Kato H, Okawa R, Ogasawara T, Hoshino Y, Hidaka N, Koga M, Kinoshita Y, Kobayashi H, Taniguchi Y, Fukumoto S, Nangaku M, Makita N, Hoshi K, Nakano K, Ito N. Effect of conventional treatment on dental complications and ectopic ossifications among 30 adults with XLH. J Clin Endocrinol Metab. 2022 Dec 16:dgac732. doi: 10.1210/clinem/dgac732. Epub ahead of print. PMID: 36524341.
  • Hoshino Y, Hidaka N, Kato H, Koga M, Taniguchi Y, Kobayashi H, Nangaku M, Makita N, Ito N. Incidence of ossification of the spinal ligaments in acromegaly patients. Bone Rep. 2022 Oct 17;17:101628. doi: 10.1016/j.bonr.2022.101628. PMID: 36299702; PMCID: PMC9589022.
  • Ashrafzadeh-Kian SL, Ito N, Srivastava T, Garg U, Kato H, Algeciras-Schimnich A, Bornhorst JA. The Effect of Burosumab on Intact and C-terminal FGF23 Measurements. Clin Endocrinol (Oxf). 2022 Oct 20. doi: 10.1111/cen.14832. Epub ahead of print. PMID: 36263608.
  • Kato H, Hoshino Y, Hidaka N, Ito N, Makita N, Nangaku M, Inoue K. Machine Learning-Based Prediction of Elevated PTH Levels Among the US General Population. J Clin Endocrinol Metab. 2022 Sep 19:dgac544. doi: 10.1210/clinem/dgac544. Epub ahead of print. PMID: 36125184.
  • Brandi ML, Jan de Beur S, Briot K, Carpenter T, Cheong HI, Cohen-Solal M, Crowley RK, Eastell R, Imanishi Y, Imel EA, Ing SW, Insogna K, Ito N, Javaid K, Kamenicky P, Keen R, Kubota T, Lachmann RH, Perwad F, Pitukcheewanont P, Portale A, Ralston SH, Tanaka H, Weber TJ, Yoo HW, Sun W, Williams A, Nixon A, Takeuchi Y. Efficacy of Burosumab in Adults with X-linked Hypophosphatemia (XLH): A Post Hoc Subgroup Analysis of a Randomized Double-Blind Placebo-Controlled Phase 3 Study. Calcif Tissue Int. 2022 Aug 4. doi: 10.1007/s00223-022-01006-7. Epub ahead of print. PMID: 35927518.
  • Hidaka N, Koga M, Kimura S, Hoshino Y, Kato H, Kinoshita Y, Makita N, Nangaku M, Horiguchi K, Furukawa Y, Ohnaka K, Inagaki K, Nakagawa A, Suzuki A, Takeuchi Y, Fukumoto S, Nakatani F, Ito N. Clinical Challenges in Diagnosis, Tumor Localization and Treatment of Tumor-Induced Osteomalacia: Outcome of a Retrospective Surveillance. J Bone Miner Res. 2022 Jun 11. doi: 10.1002/jbmr.4620. Epub ahead of print. PMID: 35690913.
  • Hofstaetter JG, Atkins GJ, Kato H, Kogawa M, Blouin S, Misof BM, Roschger P, Evdokiou A, Yang D, Solomon LB, Findlay DM, Ito N. A Mild Case of Autosomal Recessive Osteopetrosis Masquerading as the Dominant Form Involving Homozygous Deep Intronic Variations in the CLCN7 Gene. Calcif Tissue Int. 2022 May 26. doi: 10.1007/s00223-022-00988-8. Epub ahead of print. PMID: 35618777.
  • Kato H, Ansh AJ, Lester ER, Kinoshita Y, Hidaka N, Hoshino Y, Koga M, Taniguchi Y, Uchida T, Yamaguchi H, Niida Y, Nakazato M, Nangaku M, Makita N, Takamura T, Saito T, Braddock DT, Ito N. Identification of ENPP1 haploinsufficiency in patients with diffuse idiopathic skeletal hyperostosis and early-onset osteoporosis. J Bone Miner Res. 2022 Mar 26. doi: 10.1002/jbmr.4550. Epub ahead of print. PMID: 35340077.
  • Kato H, Hidaka N, Koga M, Kinoshita Y, Makita N, Nangaku M, Ito N. Radiological evaluation of pseudofracture after the administration of asfotase alfa in an adult with benign prenatal hypophosphatasia: A case report. Bone Rep. 2021 Dec 29;16:101163. doi: 10.1016/j.bonr.2021.101163. PMID: 35024386; PMCID: PMC8728307.
  • Hidaka N, Kato H, Koga M, Katsura M, Oyama Y, Kinoshita Y, Fukumoto S, Makita N, Nangaku M, Ito N. Induction of FGF23-related hypophosphatemic osteomalacia by alcohol consumption. Bone Rep. 2021 Dec 15:101144 doi: 10.1016/j.bonr.2021.101144
  • Kato H, Hidaka N, Koga M, Kinoshita Y, Nangaku M, Makita N, Ito N. Altered Thyroid Function Tests Observed in Hypophosphatasia Patients Treated with Asfotase Alfa. Int J Endocrinol. 2021 Oct 28;2021:5492267. doi: 10.1155/2021/5492267. PMID: 34745256; PMCID: PMC8568557.
  • Ito N, Kang HG, Nishida Y, Evins A, Skrinar A, Cheong HI. Burden of disease of X-linked hypophosphatemia in Japanese and Korean patients: a cross-sectional survey. Endocr J. 2021 Nov 2. doi: 10.1507/endocrj.EJ21-0386. Epub ahead of print. PMID: 34732603.
  • Kato H, Ito N, Makita N, Nangaku M, Leung AM, Inoue K. Association of Serum Parathyroid Hormone Levels with All-cause and Cause-specific Mortality Among US Adults. Endocr Pract. 2021 Sep 23:S1530-891X(21)01233-7. doi: 10.1016/j.eprac.2021.09.005. Online ahead of print.PMID: 34563702
  • Briot K, Portale AA, Brandi ML, Carpenter TO, Cheong HI, Cohen-Solal M, Crowley RK, Eastell R, Imanishi Y, Ing S, Insogna K, Ito N, Jan de Beur S, Javaid MK, Kamenicky P, Keen R, Kubota T, Lachmann RH, Perwad F, Pitukcheewanont P, Ralston SH, Takeuchi Y, Tanaka H, Weber TJ, Yoo HW, Nixon A, Nixon M, Sun W, Williams A, Imel EA. Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension. RMD Open. 2021 Sep;7(3):e001714. doi: 10.1136/rmdopen-2021-001714.PMID: 34548383
  • Koga M, Kinoshita Y, Kato H, Kobayashi H, Shinoda Y, Nangaku M, Makita N, Dahir KM, Ito N. Massive calcification around large joints in a patient subsequently diagnosed with adult-onset hypophosphatasia. Osteoporos Int. 2021 Sep 8. doi: 10.1007/s00198-021-06145-5. Online ahead of print.PMID: 34494146
  • Kato H, Hidaka N, Koga M, Ogawa N, Takahashi S, Miyazaki H, Nangaku M, Makita N, Ito N. Performance evaluation of the new chemiluminescent intact FGF23 assay relative to the existing assay system. J Bone Miner Metab. 2021 Aug 5. doi: 10.1007/s00774-021-01258-7. Online ahead of print.PMID: 34351500
  • Ito N, Kubota T, Kitanaka S, Fujiwara I, Adachi M, Takeuchi Y, Yamagami H, Kimura T, Shinoda T, Minagawa M, Okazaki R, Ozono K, Seino Y, Fukumoto S. Clinical performance of a novel chemiluminescent enzyme immunoassay for FGF23. J Bone Miner Metab. 2021 Jul 13. doi: 10.1007/s00774-021-01250-1. Online ahead of print.PMID: 34255195
  • Kinoshita Y, Mohamed FF, Amadeu de Oliveira F, Narisawa S, Miyake K, Foster BL, Millán JL. Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl-/- Mice. J Bone Miner Res. 2021 Jun 2. doi: 10.1002/jbmr.4382. Online ahead of print.PMID: 34076297
  • Kato H, Koga M, Kinoshita Y, Taniguchi Y, Kobayashi H, Fukumoto S, Nangaku M, Makita N, Ito N. Incidence of complications in 25 adult patients with X-linked hypophosphatemia. J Clin Endocrinol Metab. 2021 Apr 29:dgab282. doi: 10.1210/clinem/dgab282. Online ahead of print.PMID: 33912912
  • Ito N, Prideaux M, Wijenayaka AR, Yang D, Ormsby RT, Bonewald LF, Atkins GJ. Sclerostin Directly Stimulates Osteocyte Synthesis of Fibroblast Growth Factor-23. Calcif Tissue Int. 2021 Feb 22. doi: 10.1007/s00223-021-00823-6. Online ahead of print. PMID: 33616712
  • Kato H, Koga M, Kobayashi H, Maki H, Ikemura M, Kurokawa M, Nangaku M, Makita N, Ito N. Primary bone adult T cell lymphoma with multiple skeletal lesions and debilitating painful osteolysis: a case report. Osteoporos Int. 2021 May;32(5):1013-1017. doi: 10.1007/s00198-020-05720-6. Epub 2020 Oct 31.PMID: 33128574
  • Imanishi Y, Ito N, Rhee Y, Takeuchi Y, Shin CS, Takahashi Y, Onuma H, Kojima M, Kanematsu M, Kanda H, Seino Y, Fukumoto S. Interim Analysis of a Phase 2 Open-Label Trial Assessing Burosumab Efficacy and Safety in Patients With Tumor-Induced Osteomalacia. J Bone Miner Res. 2021 Feb;36(2):262-270. doi: 10.1002/jbmr.4184. Epub 2020 Nov 4.PMID: 32967046
  • Kobayashi H, Makise N, Ito N, Koga M, Zhang L, Ishibashi Y, Ikegami M, Shinoda Y, Akiyama T, Ushiku T, Tanaka S. Surgical margin for phosphaturic mesenchymal tumors in soft tissues: An analysis of the radiological histopathological correlation. J Orthop Sci. 2020 Aug 11:S0949-2658(20)30195-0. doi: 10.1016/j.jos.2020.07.006. Online ahead of print.J Orthop Sci. 2020. PMID: 32798110
  • Kubota T, Fukumoto S, Cheong HI, Michigami T, Namba N, Ito N, Tokunaga S, Gibbs Y, Ozono K. Long-term outcomes for Asian patients with X-linked hypophosphataemia: rationale and design of the SUNFLOWER longitudinal, observational cohort study. BMJ Open. 2020 Jun 29;10(6):e036367. doi: 10.1136/bmjopen-2019-036367. PMID: 32601114
  • Ito N, Fukumoto S. Congenital Hyperphosphatemic Conditions Caused by the Deficient Activity of FGF23. Calcif Tissue Int. 2021 Jan;108(1):104-115. doi: 10.1007/s00223-020-00659-6. Epub 2020 Jan 22.PMID: 31965220 Review.
  • Kobayashi H, Hirai T, Makise N, Ushiku T, Ito N, Koga M, Ikegami M, Shinoda Y, Akiyama T, Tanaka S.　Reconstruction Using Frozen Autograft for Disseminated Phosphaturic Mesenchymal Tumor of the Humerus after a Pathological Fracture.Case Rep Orthop. 2019 Sep 4;2019:3015675. doi: 10.1155/2019/3015675. eCollection 2019.PMID:31565455
  • Sahoo SK, Kushwaha P, Bharti N, Khedgikar V, Trivedi R, Agrawal V, Ahmad N, Zaidi G, Paul L, Ito N, Bhatia E.　Elevated FGF23 in a patient with hypophosphatemic osteomalacia associated with neurofibromatosis type 1.　Bone. 2019 Dec;129:115055. doi: 10.1016/j.bone.2019.115055. Epub 2019 Aug 30.　PMID:31476437
  • Insogna KL, Rauch F, Kamenický P, Ito N, Kubota T, Nakamura A, Zhang L, Mealiffe M, San Martin J, Portale AA.　Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial.J Bone Miner Res. 2019 Dec;34(12):2183-2191. doi: 10.1002/jbmr.3843. Epub 2019 Oct 1. 　PMID:31369697
  • Portale AA, Carpenter TO, Brandi ML, Briot K, Cheong HI, Cohen-Solal M, Crowley R, Jan De Beur S, Eastell R, Imanishi Y, Imel EA, Ing S, Ito N, Javaid M, Kamenicky P, Keen R, Kubota T, Lachmann R, Perwad F, Pitukcheewanont P, Ralston SH, Takeuchi Y, Tanaka H, Weber TJ, Yoo HW, Zhang L, Theodore-Oklota C, Mealiffe M, San Martin J, Insogna K. Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period. Calcif Tissue Int. 2019 Sep;105(3):271-284. doi: 10.1007/s00223-019-00568-3. 2019 Jun 4. PMID:31165191
  • Takashi Y, Kosako H, Sawatsubashi S, Kinoshita Y, Ito N, Tsoumpra MK, Nangaku M, Abe M, Matsuhisa M, Kato S, Matsumoto T, Fukumoto S. Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11418-11427. PMID:31097591
  • Manaka K, Sato J, Kinoshita Y, Ito N, Fujita M, Iiri T, Nangaku M, Makita N. Effectiveness and safety of cinacalcet for primary hyperparathyroidism: a single center experience. Endocr J. 2019 Aug 29;66(8):683-689. doi: 10.1507/endocrj.EJ19-0034. Epub 2019 May 16.  PMID:31092749
  • Kobayashi H, Makise N, Ushiku T, Ito N, Koga M, Shinoda Y, Tanaka S. Infiltrative nature of tumor-induced osteomalacia lesions in bone: Correlation between radiological and histopathological features. J Orthop Sci. 2019 Sep;24(5):900-905. doi: 10.1016/j.jos.2019.02.005. Epub 2019 Feb 21.　PMID:30797665
  • Kinoshita Y, Takashi Y, Ito N, Ikegawa S, Mano H, Ushiku T, Fukayama M, Nangaku M, Fukumoto S.　Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO).　Bone Rep. 2018; 31;10:100192. PMID:30627598
  • Insogna KL, Briot K, Imel EA, Kamenický P, Ruppe MD, Portale AA, Weber T, Pitukcheewanont P, Cheong HI, Jan de Beur S, Imanishi Y, Ito N, Lachmann RH, Tanaka H, Perwad F, Zhang L, Chen CY, Theodore-Oklota C, Mealiffe M, San Martin J, Carpenter TO; AXLES 1 Investigators. A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis J Bone Miner Res. 2018; 33: 1383-1393. PMID:29947083
  • Kinoshita Y, Fukumoto S. X-linked hypophosphatemia and FGF23-related hypophosphatemic diseases -Prospect for new treatment. Endocr Rev. 2018; 39 :274-291. PMID:29381780
  • Kobayashi H, Ito N, Akiyama T, Okuma T, Kinoshita Y, Ikegami M, Shinoda Y, Fukumoto S, Tanaka S, Kawano H. Prevalence and clinical outcomes of hip fractures and subchondral insufficiency fractures of the femoral head in patients with tumour-induced osteomalacia. Int Orthop. 2017;　41:　2597-2603.　PMID:28836028
  • Kinoshita Y, Ito N, Makita N, Nangaku M, Fukumoto S.　Changes in bone metabolic parameters following oral calcium supplementation in an adult patient with vitamin D-dependent rickets type 2A.　Endocr J. 2017; 64: 589-596.　PMID:28367941
  • Takashi Y, Kinoshita Y, Ito N, Taguchi M, Takahashi M, Egami N, Tajima S, Nangaku M, Fukumoto S. Tumor-induced Osteomalacia Caused by a Parotid Tumor. Intern Med. 2017; 56: 535-539.
  • Kobayashi H, Akiyama T, Okuma T, Shinoda Y, Oka H, Ito N, Fukumoto S, Tanaka S, Kawano H. Three-dimensional fluoroscopic navigation-assisted surgery for tumors in patients with tumor-induced osteomalacia in the bones. Comput Assist Surg (Abingdon). 2017; 12: 1-14.
  • Takashi Y, Kinoshita Y, Hori M, Ito N, Taguchi M, Fukumoto S. Patients with FGF23-related hypophosphatemic rickets/osteomalacia do not present with left ventricular hypertrophy. Endocr Res. 2017; 42: 132-137.
  • Kinoshita Y, Arai M, Ito N, Takashi Y, Makita N, Nangaku M, Shinoda Y, Fukumoto S. High serum ALP level is associated with increased risk of denosumab-related hypocalcemia in patients with bone metastases from solid tumors. Endocr J. 2016; 63: 479-484.
  • Hori M, Kinoshita Y, Taguchi M, Fukumoto S. Phosphate enhances Fgf23 expression through reactive oxygen species in UMR-106 cells. J Bone Miner Metab. 2016; 34: 132-139.
  • Tajima S, Takashi Y, Ito N, Fukumoto S, Fukuyama M. ERG and FLI1 are useful immunohistochemical markers in phosphaturic mesenchymal tumors. Med Mol Morphol. 2016; 49: 203-209.
  • Wijenayaka AR, Yang D, Prideaux M, Ito N, Kogawa M, Anderson PH, Morris HA, Solomon LB, Loots GG, Findlay DM, Atkins GJ. 1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion. Mol Cell Endocrinol 2015; 413: 157-167.
  • Takashi Y, Kinoshita Y, Makita N, Taguchi M, Takahashi K, Nangaku M, Fukumoto S. Rapid Recovery of Hypothalamic-Pituitary Axis after Successful Resection of an ACTH-secreting Neuroendocrine Tumor. Intern Med 2015; 54: 2201-2205.
  • Ito N, Wijenayaka AR, Prideaux M, Kogawa M, Ormsby RT, Evdokiou A, Bonewald LF, Findlay DM, Atkins GJ. Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli. Mol Cell Endocrinol. 2015; 399: 208-218.
  • Nakamura T, Aizawa T, Hoshikawa T, Ozawa H, Ito N, Fukumoto S, Itoi E, Kokubun S.　Tumor-induced osteomalacia caused by phosphaturic mesenchymal tumor of the cervical spine. J Orthop Sci. 2015; 20: 765-771. PMID: 24504987
  • Kinoshita Y, Hori M, Taguchi M, Fukumoto S. Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia. Bone. 2014; 67: 145-151.
  • Ito N, Peña AS, Perano S, Atkins GJ, Findlay DM, Couper JJ. First Australian report of vitamin D-dependent rickets type I. Med J Aust. 2014; 201: 420-421.
  • Kinoshita Y, Hori M, Taguchi M, Watanabe S, Fukumoto S. Functional activities of mutant calcium-sensing receptors determine clinical presentations in patients with autosomal dominant hypocalcemia. J Clin Endocrinol Metab. 2014; 99: E363-368.
  • Ito N, Findlay DM, Atkins GJ. Osteocyte Communication with the Kidney Via the Production of FGF23: Remote Control of Phosphate Homeostasis. Clin Rev Bone Miner Metab. 2014; 12: 44-58.
  • Ito N, Findlay DM, Anderson PH, Bonewald LF, Atkins GJ. Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D(3) (1,25D) on osteocyte like cells. J Steroid Biochem Mol Biol. 2013; 136: 183-186.
  • Kinoshita Y, Saito T, Shimizu Y, Hori M, Taguchi M, Igarashi T, Fukumoto S, Fujita T. Mutational analysis of patients with FGF23-related hypophosphatemic rickets. Eur J Endocrinol. 2012; 167: 165-172.
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